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Studies · Fibrin · Discseel Procedure · Personal injury
Studies on fibrin and the Discseel Procedure.
Cited papers on fibrin and the Discseel Procedure. PubMed or PMC when the paper is indexed. Nothing invented — no fake years, journals, or success rates. For personal injury and car accident patients on this portal.
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How to read this page
What was studied. What happened. In numbers only if the paper states them.
A patient trial followed people after fibrin was placed in a disc. A lab or animal study did not. Links go to PubMed or the journal — that is a citation, not a send-off to another clinic site. Inquire stays on this patient portal.
Discseel Procedure clinical reports
Papers that followed patients after fibrin in the disc.
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Patient study
Long-term Investigation of Annulargrams and Intra-annular Fibrin to Treat Chronic Discogenic Low Back Pain and Radiculopathy
Pauza K, Boachie-Adjei K, Nguyen JT, Hussey IV F, Sutton J, Serwaa-Sarfo A, Ercole PM, Wright C, Murrell WD. Pain Physician. 2024;27(8):537–553. PubMed 39621982
People who had already failed other treatments were followed for one, two, and three years after fibrin was placed in disc tears. Pain and function scores improved at each year. At 12 months, 50% reached a meaningful improvement on the disability questionnaire (ODI). No severe side effects were reported. Average pain before treatment: 11.2 years.
Quoted from the PubMed abstract. Discseel.com’s FAQ also calls this a 2024 study of over 700 patients; that “over 700” is their wording, not a number printed in the PubMed abstract.
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Patient study · 15 people
Intradiscal injection of fibrin sealant for the treatment of symptomatic lumbar internal disc disruption
Yin W, Pauza K, Olan WJ, Doerzbacher JF, Thorne KJ. Pain Medicine. 2014;15(1):16–31. PubMed 24152079
A 15-person pilot of fibrin injected into painful lumbar discs. Average back-pain score (0–100) fell from 72.4 to 33.0 at two years. Disability score fell from 15.2 to 5.6. The authors said it appears safe and may improve pain and function. Nine people reported some side effect; two muscle spasms and one disc infection were judged related to the product or procedure.
Quoted from the PubMed abstract. This is the BIOSTAT fibrin pilot. It is not the later Discseel registry paper above.
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Patient / disc-pressure report · no PMID
Treatment of annular disc tears and “leaky disc syndrome” with fibrin sealant
Pauza K, Wright C, Fairbourn A. Techniques in Regional Anesthesia and Pain Management. DOI 10.1053/j.trap.2016.09.008. No PubMed ID found. Listed on Discseel.com research.
The authors asked whether fibrin can glue a tear in the disc wall. In a pressure test of 347 discs, mean pressure the disc could hold rose from 75.84 to 179.3 kilopascals after fibrin. They write that sealing the tear can keep the inner disc gel from leaking. Average number of abnormal lumbar discs in that chronic-pain group: 3.21.
Numbers quoted from the abstract Discseel.com publishes for this paper. Not indexed on PubMed.
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Book chapter · not a new patient trial
Intra-annular Fibrin Discseel
Pauza KJ, Moradian M, Lutz G. In: Hunter CW et al., eds. Regenerative Medicine. Springer Nature Switzerland AG; 2023. DOI 10.1007/978-3-030-75517-1_6. Listed on Discseel.com research as the Pauza / Moradian / Lutz heading.
A textbook chapter — not a new patient trial. It describes the Discseel Procedure as two steps: find tears with an Annulargram, then inject fibrin into every torn disc in the painful region.
Quoted from the chapter opening as Discseel.com and hosted copies print it.
Fibrin and annular science
Lab, animal, and other-clinic fibrin papers listed with the procedure.
These are on Discseel.com’s research page. They study fibrin in discs or disc cells. They are not Discseel Procedure patient trials unless noted.
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Lab / animal study · not a patient trial
Biological and biomechanical effects of fibrin injection into porcine intervertebral discs
Buser Z, Kuelling F, Liu J, Liebenberg E, Thorne KJ, Coughlin D, Lotz JC. Spine. 2011;36(18):E1201–9. PubMed 21325992
Lab study in 31 minipigs, not a patient trial. Fibrin was injected into surgically damaged pig discs. Treated discs recovered stiffness and leak pressure toward normal by 6 and 12 weeks and made less of an inflammatory chemical (TNF-α: 66% vs 226% in damaged discs without fibrin).
Quoted from the PubMed / Europe PMC abstract. Discseel.com also lists the 2009 Spine Journal meeting abstract of this same pig work (no PMID).
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Other-clinic patient study · not Discseel Procedure
Fibrin sealants in lumbar annuloplasty after endoscopic discectomy
Torkian P, Daneshvar K, Taherian E, Rezaeifar Y, Akhlaghpoor S. European Journal of Translational Myology. 2020;30(2):8748. PubMed 32782757 · PMC 7385697
Thirty-five people had endoscopic disc surgery; 17 also got fibrin on the tear. Follow-up averaged 10.5 months. Re-herniation: 1 of 18 without fibrin, 2 of 17 with fibrin. The authors still suggested fibrin might help prevent early re-herniation. This is not a Discseel Procedure trial.
Quoted from the abstract Discseel.com copies and from PMC.
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Review · not a patient trial
Fibrin in intervertebral disc tissue engineering
Colombini A, Ceriani C, Banfi G, Brayda-Bruno M, Moretti M. Tissue Engineering Part B: Reviews. 2014;20(6):713–721. PubMed 24961887
A review of lab and animal papers, not a patient trial. The authors say fibrin can keep disc cells alive and help them make new disc matrix. As of 2014 they wrote that human disc cells had not yet been used with fibrin in a clinical trial.
Quoted from the PubMed abstract.
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Lab study · not a patient trial
Human disc cells in clinical-grade fibrin and collagen-enriched fibrin gels
Colombini A, Lopa S, Ceriani C, Lovati AB, Croiset SJ, Di Giancamillo A, Lombardi G, Banfi G, Moretti M. Tissue Engineering Part A. 2015;21(3–4):793–802. PubMed 25236589
Lab study, not a patient trial. Human disc cells were still alive in fibrin gels 28 days after implant in mice and made typical disc proteins (GAGs and collagen I and II).
Quoted from the PubMed abstract.
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Lab study · not a patient trial
Fibrin promotes proliferation and matrix production of intervertebral disc cells in a PLGA scaffold
Sha'ban M, Yoon SJ, Ko YK, Ha HJ, Kim SH, So JW, Idrus RB, Khang G. Journal of Biomaterials Science, Polymer Edition. 2008;19(9):1219–1237. PubMed 18727862
Lab study, not a patient trial. Disc cells grown with fibrin in a scaffold multiplied more and made more cartilage-like matrix than cells without fibrin.
Quoted from the PubMed abstract.
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Lab study · not a patient trial
Incorporation of collagen and hyaluronic acid to enhance fibrin hydrogels for nucleus pulposus regeneration
Gansau J, Buckley CT. Journal of Functional Biomaterials. 2018;9(3):43. PubMed 29996555 · PMC 6164980
Lab study, not a patient trial. Higher fibrin concentration helped cells live and multiply. Adding hyaluronic acid helped them make more of the sugar-rich matrix found in the disc center.
Quoted from the PMC abstract. Title listed on Discseel.com research.
Manufacturer homepage figures (12,500+ procedures, >82% success) are Discseel.com claims, not outcomes from a named paper on this list. A 320-subject registry write-up appears on Discseel.com under the 2014 Yin title; no PubMed record was found for that write-up, so it is not listed as a paper here.
Personal injury · Motor vehicle accident
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